Higuchi connors phase solubility techniques

Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, pp. 117-212. Google Scholar

The linear phase solubility diagram follows the A L-type model according to Higuchi and Connors (1965), suggesting the inclusion complex formed between BBH (guest) and β-CD (host) is in molar ratio of 1:1. It is well-known that the most common type of CDs complexes is the 1:1 drug/cyclodextrin complex where one drug molecule forms a …Phase solubility studies. The phase solubility studies were performed using Higuchi and Connors method (Higuchi & Connors, 1965). Briefly, different …Phase solubility studies in distilled water were conducted according to the method of Higuchi and Connors . Excess amounts of diosmin were added to a series of glass vials containing 10.0 mL of distilled water. ... Higuchi T, Connors KA. Phase solubility techniques. Adv. Anal. Chem. Instrum. 1965; 4:117–212. [Google Scholar] 26. Doile KM ...One of the most useful and widely applied analytical approaches in this context is the Phase–solubility method described by Higuchi and Connors [42].... Journal Article • DOI • Cyclodextrins in drug delivery: an updated review. Phase Solubility Studies. Phase solubility studies were carried out based on the methods described by Higuchi and Connors . Excess amount of POS (30 mg) was added to aqueous solutions of β-CD and DM-β-CD with various concentrations (0 to 15.00 mM for β-CD and 0 to 35.00 mM for DM-β-CD).Higuchi T, Connors KA. Phase solubility techniques. Adv Anal Chem Instrum 1965;4:117-212. 10. Asker AF, Whitworth CW. Dissolution of acetyl salicylic acid from acetyl salicylic acid-polyethylene glycol 6000 coprecipitates. Pharmazie 1975;30:530-1. ... T. Higuchi, K.A. Connors. Phase solubility techniques. Adv Anal Chem Instrum, 4 …

Phase solubility studies. Phase solubility studies of stigmasterol with different concentrations of α-CD were determined by the method proposed by Higuchi and Connors at room temperature. The excess amount of stigmasterol was dissolved in 60 ml of ethanol and then added to 10 ml of double-distilled water containing various concentrations of α ...Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, pp. 117-212. Google ScholarThe phase-solubility profiles were determined according to Higuchi & Connors 1965 and Brewster and Loftsson, 2007 [22, 23]. ... Higuchi T, Connors KA. Phase-solubility techniques. Adv Anal Chem Instrum. 1965;4:117–212. Google Scholar Hassan E, Gallo J. A simple rheological method for the in vitro assessment of mucin …Solubility studies used deionized water, and 1 H NMR spectra were of solutions in deuterium oxide (D 2 O, deuterium content 99.8%) from Fluka (Barcelona, Spain). 2.2. Phase solubility studiesSolubility measurements were carried out according to the method of Higuchi and Connors (1965). Excess amounts of clofibrate were added to a series of ...according to Higuchi and Connors (10). Briefly, an excess amount of paracetamol ... Phase solubility techniques. In: Reilley CN. (ed.) Advances in Analytical ...[Article] - Phase Solubility Techniques . I'm having a really hard time even finding a link to this article, but everyone cites it: Higuchi, T.; Connors, K. A., 1965. Adv. Anal. Chem. Instrum. 4, 117-212. comment sorted by Best Top New Controversial Q&A Add a …T. Higuchi and K. A. Connors, “Phase-Solubility Techniques,” In: C. N. Reilly, Ed., Advances in Analytical Chemistry and Instrumentation, Wiley-Interscience, New York, …

Phase Solubility Studies. The solubilization ability of CDs can be quantitatively evaluated by the phase solubility method developed by Higuchi and Connors ().The phase solubility diagram at 25 °C was obtained by plotting the apparent equilibrium concentrations of the drug against βCD concentrations and is reported in Fig. …Higuchi T, Connoras KA. Phase-solubility techniques, ADV Anal Chem Instrum, 1965, 4, 117-210. has been cited by the following article: Article. Solid Dispersion Incorporated Microcapsules: Predictive Tools for Improve the Half Life and Dissolution Rate of Pioglitazone Hydrochloride.Guest–host interaction of astemizole (Astm) with cyclodextrins (CDs) has been investigated using phase solubility diagrams (PSD), differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD), proton nuclear magnetic resonance (1H-NMR) and molecular mechanical modeling (MM+). Estimates of the complex formation …method described by Higuchi & Connors et al [18]. Excess NSF (100 mg) was added to a 50 m L . ... [18] Higuchi T and Connors K A 1965 Phase solubility techniques Advances in Analyt ical Chemistry .The solubilizing potential and complexing tendencies of six cyclodextrins (CyD) with nifedipine in aqueous solution were evaluated using phase solubility methods. Solubility curves of nifedipine with β-CyD, 2-hydroxypropyl-β-CyD (2HP-β-CyD) and 2-hydroxypropyl-γ-cyclodextrin (2HP-γ-CyD) were classified as type AL, while for heptakis (2,6-dimethyl) …

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ResearchGate | Find and share researchThe phase solubility results indicated the formation of a IDE/SBE-β-CD inclusion complex with 1:1 molar ratio (A L type diagram), whose apparent stability constants at T = 300, 310, and 320 K have been estimated according to the Higuchi–Connors method. The formation of the inclusion complex has been confirmed on a freeze-dried …11 Tem 2017 ... Higuchi T, Connors KA. Phase solubility techniques. Advances in Analytical Chemistry and Instrumen- tation. New York, pp. 117–212 ...In present work, phase solubility analysis were conducted for studying the solubility of terpineol, a natural flavor compound with antifungal and disinfectant action, in 2-hydroxypropyl-β-cyclodextrin (HBCD) and in β-cyclodextrin (BCD) aqueous solutions and for calculating the thermodynamic parameters involved in the complex formation.Using the concept proposed by Higuchi and Connors , the solubility diagrams can be classified as the AL type. The observed increase of the drug solubility results from the formation of a drug-cyclodextrin inclusion complex with a stoichiometry of 1:1. ... Higuchi, T.; Connors, K.A. Phase solubility techniques. Adv. Anal. Chem. …

Phase solubility techniques. T. Higuchi, A. Connors. Published 1965. Chemistry. No Paper Link Available. Save to Library. Create Alert. Cite. 2,644 Citations. Citation Type. More Filters. Environmentally friendly stability-indicating HPLC method for the …Phase solubility techniques @inproceedings{Higuchi1965PhaseST, title={Phase solubility techniques}, author={Takeru. Higuchi and Andrew L. Connors}, year={1965}, url={https://api.semanticscholar.org/CorpusID:100897505} } T. Higuchi, A. Connors; Published 1965; Chemistry Higuchi T, Connors K A 1965 Phase solubility techniques Advances in Analytical. Chemistry and Instrumentation vol 4(1) pp 117-212. 9. ITM Web of Conferences 45 ...The phase solubility diagram (Fig. 2) showed that the solubility of cholesterol increased linearly with increasing β-CD concentration from 0 to 18 mmol/L (R 2 > 0.99). The phase solubility diagram was defined as the A L -type phase based on the early research of Higuchi and Connors (1965) , revealing the formation of inclusion complex …HIGHLIGHTS Enhanced curcumin solubility up to 190 fold higher than pure curcumin was investigated The phase solubility results of curcumin range from 5.7×10-4 M-1 and 7.8×10-4 M-1 at 25 and 37 °C, respectively First time of novel dyeing test was performed with complex of curcumin, signified its solubility This study provides useful …also calculated whe re possible accordin g to Higuchi-Connors. 8 The methodolog y employed for . ... Connors KA. Phase Solubility Techniques. Advances in Analytical Chemistry and Instrumentation ...Phase solubility study. Phase solubility studies were carried out according to the method reported by Higuchi and Connors . Excess amounts of MMF were added to 0.1 N HCl solutions (pH-1.2) containing para sulphonatocalix[4]resorcinarene in different molar concentrations and these flasks were then sonicated for 1 h and shaken at a rate …Higuchi T, Connors KA. Phase solubility techniques. Adv Anal Chem Instrum 1965;4:117-212. 10. Asker AF, Whitworth CW. Dissolution of acetyl salicylic acid from acetyl salicylic acid-polyethylene glycol 6000 coprecipitates. Pharmazie 1975;30:530-1. ... T. Higuchi, K.A. Connors. Phase solubility techniques. Adv Anal Chem Instrum, 4 …PHASE-SOLUBILITY TECHNIQUES HIGUCHI TK,CONNORS A. Keyword. 出版时间：. 1965/01/01. 被引量：. 2861. 收藏 引用 批量引用 报错 分享. 全部来源 求助全文. ResearchGate scienceopen.com sid.ir. The phase solubility technique permits the evaluation of the affinity between HPβCD and raloxifene in water. Phase solubility studies were performed according to the method reported by Higuchi and Connors . As given in Table 1, raloxifene was taken into vials in an excess amount, and 20 ...In present work, phase solubility analysis were conducted for studying the solubility of terpineol, a natural flavor compound with antifungal and disinfectant action, in 2-hydroxypropyl-β-cyclodextrin (HBCD) and in β-cyclodextrin (BCD) aqueous solutions and for calculating the thermodynamic parameters involved in the complex formation.HIGHLIGHTS Enhanced curcumin solubility up to 190 fold higher than pure curcumin was investigated The phase solubility results of curcumin range from 5.7×10-4 M-1 and 7.8×10-4 M-1 at 25 and 37 °C, respectively First time of novel dyeing test was performed with complex of curcumin, signified its solubility This study provides useful …

Phase solubility analysis was performed according to the method reported by Higuchi and Conners . An excess amount of RIF was added into a glass vial containing 1 mL of PBS solution (pH = 7.4) with various concentrations of ACB (0, 20, 40, 60, 80, 100 mM, respectively). ... Higuchi, T., Connors, K.A.: Phase-solubility techniques. Adv. …

Phase-solubility measurementsPhase-solubility measurements were carried out according to the method of Higuchi and Connors. 14 Excess amount of 5-NI (5 mg) was added to 5 mL of deionized water containing increasing amounts of βCD and DM-βCD (ranging from 0 to 0.010 M).Feb 5, 2008 · Phase Solubility Studies. The solubilization ability of CDs can be quantitatively evaluated by the phase solubility method developed by Higuchi and Connors . The phase solubility diagram at 25 °C was obtained by plotting the apparent equilibrium concentrations of the drug against βCD concentrations and is reported in Fig. 1. The regression analysis (R 2 value 0.9434) of phase solubility data demonstrated A L type curves (Fig. 1 (a)) indicating 1:1 complexation between NCL and HP-β-CD as per Higuchi Connors classification (Higuchi & Connors, 1965). The apparent stability constant of the resultant niclosamide and HP-β-CD complex was found to be 747 M −1.Phase solubility evaluates the solubility of insoluble guest molecule in the presence of cyclodextrin. It can be obtained by studying the relationship between the guest molecule (1,8-cineole) and the host molecule (HP-β-CD) in the solution, and the stability of IC can be evaluated by stability constant (K s ) ( Higuchi & Connors, 1965 ).7 May 2015 ... ... solubility method (Higuchi and Connors 1965). Figure 1 shows the phase ... Higuchi T, Connors KA (1965) Phase-solubility techniques. Adv Anal ...Jul 11, 2017 · Phase solubility study. The effect of complexation with βCD and HPβCD on the solubility of GA was assessed. The phase solubility diagram was used in order to evaluate the solubility of GA in the presence of CDs according to Higuchi & Connors . The amount of GA was kept in excess and mixed up with different concentrations of βCD (0–16 mM ... Shake flask method was employed for the aqueous solubility measurements, performed in triplicates by Higuchi and Connors method . An excess amount of cocrystals were added to the flask containing distilled water. The solutions were vortexed for 2 min and placed on a rotary shaker at 100 rpm and 27±0.5° for 24 h. ... Higuchi TK, Connors A. …To determine binding constants by Higuchi and Connors method, the acids solubility was determined by CZE after their agitation in the solutions of HP-γ-CD (with 0.6 molar substitution) at 25 °C for 3 days. The dependences of acids solubility on HP-γ-CD concentration deviated from straight line in the range of high concentration (A N mode ...

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The phase solubility technique permits the evaluation of the affinity between HPβCD and raloxifene in water. Phase solubility studies were performed according to the method reported by Higuchi and Connors . As given in Table 1, raloxifene was taken into vials in an excess amount, and 20 ...Phase solubility studies of stigmasterol with different concentrations of α-CD were determined by the method proposed by Higuchi and Connors at room temperature. The excess amount of stigmasterol was dissolved in 60 ml of ethanol and then added to 10 ml of double-distilled water containing various concentrations of α-CD and taken in …Phase solubility test was performed according to the method of Higuchi and Connors . An excess amount of camphor was added to aqueous CD (HPβCD and HPγCD) solutions, and the suspensions were shaken at RT. After equilibrium was achieved at the end of 48 h, the suspensions were filtered with 0.45 μm membrane filter.Phase solubility studies in distilled water were conducted according to the method of Higuchi and Connors . Excess amounts of diosmin were added to a series of glass vials containing 10.0 mL of distilled water. ... Higuchi T, Connors KA. Phase solubility techniques. Adv. Anal. Chem. Instrum. 1965; 4:117-212. [Google Scholar] 26. Doile KM ...Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. About: The article was published on 1965-01-01 and is currently open access. It has received 2363 citation (s) till now. The article focuses on the topic (s): Phase (matter) & Solubility. 2.3 Phase solubility studies. Phase solubility studies were carried out according to the method described by Higuchi and Connors (1965). 21 Excess amounts of EO were added to CD solutions at different concentrations ranging from 0 to 40mM. The mixtures were shaken overnight at 25°C and then filtered through a 0.45 μm membrane filter.Higuchi a nd K. A. Connors, “Phase-solubility techniques, ” Advanc es in Ana lyti cal Ch emi str y and Inst rume ntati on ,v o l . , p p . – , .The phase solubility studies were performed according to the method described by Higuchi and. Connors [24]. Different concentrations of β-CD and HPβ-CD were ...The shake-fl ask method proposed by Higuchi and Connors is the most reliable and widely used solubility measurement method. ... K. A. Connors, Phase-solubility techniques, Adv. Anal. Chem. Instr ...The phase solubility curve was a typical AL-type curve, as described in solubility diagrams by Higuchi and Connors. A regression coefficient (R 2) exceeding 0.99 and slope value (0.0732) of less than 1 revealed the formation of the KME/HP-β-CD system with a 1:1 stoichiometry. The Ks of KME/HP-β-CD were calculated based on the …The phase solubility investigation was carried out according to Higuchi and Connors approach . Excess DoN was added to distilled water containing various concentrations of Kollidon VA 64 in 20-mL capped bottles, stirred for 48 h at 25 and °C on magnetic stirrer, filtered, and spectrophotometrically analyzed at 283 nm using a double … ….

Types of phase-solubility diagrams according to Higuchi and Connors showing how the total drug solubility changes with increasing CD concentration. A-type diagrams are formed when the drug/CD complex is soluble in the aqueous complexation media and they are usually associated with the water-soluble CD derivatives.J Chem Educ 78(11): pharmaceuticals. Boca Raton, Florida: Taylor and Francis 1499. Group, LLC. Higuchi T, Connors KA (1965) Phase-solubility techniques. ACD/ChemSketch (2009) Version 12.01. Adv Anal Chem Instrum 4: 117–212.The equilibrium solubility is based on the phase-solubility technique proposed by Higuchi-Connors. Method Drug dispersed in solvent in a closed container ...Phase solubility analysis The solubility measurements were performed according to the The phase solubility diagram of SMX and HP-␤-CD, obtained by method of Higuchi and Connors [22] in aqueous solutions contain- plotting the changes in guest solubility as a function of HP-␤-CD ing different concentrations of HP-␤-CD, ranging from 14.3 mM ...The phase solubility study of CDL with PSC[4]arene and PSC[6]arene were executed according to Higuchi and Connors . Phase solubility studies were accomplished at 27 °C temperature, in triplicate. Excess quantity of CDL (250 mg) was added into different conical flasks containing 150 mL aqueous solutions of PSC[4]arene and PSC[6]arene at …The Higuchi–Connors phase-solubility method8) is very often used to ... The phase-distribution method is a very versatile and fast method and has the advantage, ...Feb 5, 2008 · Phase Solubility Studies. The solubilization ability of CDs can be quantitatively evaluated by the phase solubility method developed by Higuchi and Connors . The phase solubility diagram at 25 °C was obtained by plotting the apparent equilibrium concentrations of the drug against βCD concentrations and is reported in Fig. 1. See Full PDFDownload PDF. Open Access Journal Indian Journal of Medical Research and Pharmaceutical Sciences November 2018;5 (11) ISSN: ISSN: 2349-5340 DOI: 10.5281/zenodo.1490679 Impact Factor: 4.054 PHASE SOLUBILITY ASSESSMENT OF POSACONAZOLE Mohammed Hamed Mohiuddin1 & Shailesh Sharma2 Dept. of Pharmaceutical Sciences, Nims University ...Higuchi, K.A. Connors, Phase solubility techniques Advances in Analytical Chemistry and Instrumentation 4: (1965) 127-212 4. F. Djedaïni, B. Perly, Nuclear Magnetic Resonance of cyclodextrin derivatives and inclusion compounds D. Duchene, New Trends in Cyclodextrins and Derivatives (1992) Editions de Santé Paris Ch. 6 5. Higuchi connors phase solubility techniques, [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1]